Through a multidisciplinary approach, the network conducts functional studies using experimental and clinical models on Earth (known as terrestrial analogs) as well as low-Earth orbit experiments and AI-driven in silico studies. These efforts aim to understand how changes in gravity, radiation exposure, and other conditions during spaceflight or on the Moon and Mars affect human immune responses, metabolism, musculoskeletal integrity, and cardiovascular function.

In addition, the network actively develops preventive and therapeutic strategies to mitigate spaceflight-associated pathological processes, including immunosuppression and accelerated aging.